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Glucosamine hydrochloride, or glucosamine HCL is an amine salt used as a pH adjuster, anti-static agent and hair conditioner. This ingredient may help treat psoriasis and may have anti-inflammatory properties.

Glucosamine HCL has demonstrated an increase in the secretion of collagen, the principal supportive protein of skin. The tangible result of this improved hydration is a diminishment of the appearance of fine lines and wrinkles in the face. – (From Garden of Wisdom, source needed)

N-acetyl glucosamine and N-aceytl glucosamine, glucosamine sulfate are stable forms of this ingredient. Don’t confuse N-acetyl glucosamine with other forms of glucosamine, such as glucosamine hydrochloride or glucosamine sulfate. They may not have the same effects.

Four types of glucosamine amino sugars are most frequently used in cosmetic products: GlcN, GlcN.HCl, GlcN.sulfate, and N-acetyl-GlcN.
Functions according to CosIng database:
– skin conditioning (N-Ac-GlcN, GlcN.sulfate)
– antistatic (GlcN, GlcN.HCl)
– hair conditioning (GlcN, GlcN.HCl)
– Anti-aging ingredient (N-acetyl-GlcN) with anti-oxidant
properties (Rivers, 2008)

Creams containing high concentrations (8%, 10%) of GlcN salts (GlcN.HCl and GlcN.sulfate) are available on the market. Development of proprietary transdermal delivery systems is claimed to be key to the functional properties of these high concentrations of GlcN compounds. Marketers of these products claim that GlcN creams with less than 7% GlcN may not have pharmaceutical benefits. (Gupta, 2004).

It’s important to note that while glucosamine is normally found in shellfish, it can also be created from the fermentation of corn, according to Wikipedia.

Glucosamine (GlcN) Risk Profile

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