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Grape extract contains chemical constituents such as proanthocyanidins, polyphenols, flavonoids, and anthocyanins, all of which are very potent antioxidants. Grape extract has also been shown to have wound-healing properties.

When combined with other antioxidants, it reduces biomarkers in skin that are responsible for skin cancer. Red grapes contain resveratrol. Resveratrol is considered a very potent antioxidant and is believed to be the component responsible for the health benefits of red wine (and grape juice).

Topical application of grapeseed extract to a cultured human skin equivalent showed evidence of younger skin, including enhanced synthesis of healthy collagen, elastin, and improvement in many other structural components of skin.

Cancer Prevention Research, February 2010, pages 170–178
Phytotherapy Research, September 2009, pages 1,197–1,204
Carcinogenesis, June 2009, pages 1,008–1,015
Molecular Nutrition and Food Research, June 2008, pages S71–S76
Biogerontology, April 2007, pages 97–109
Free Radical Biology and Medicine, July 2001, pages 38–42
Current Pharmaceutical Biotechnology, June 2001, pages 187–200
Toxicology, August 2000, pages 187–197

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