Hesperidin Methyl Chalcone is a bioflavinoid that is found in naturally high concentrations in the peel, pulp, and membranes of citrus fruit, such as grapefruits, lemons, and oranges. It’s used in products marketed to banish dark circles because studies showed that when ingested (via oral supplements) it can help varicose vein problems, among many other conditions. One study documented that it lowers the filtration rate of capillaries – when ingested, not applied topically to your skin. Why is this good? Less blood flowing though capillaries close to the surface of the skin potentially means that less hemoglobin would be oxygenated to cause the dark bluish discoloration under the eyes.
However, there is no research proving this will happen if you apply a product containing this ingredient to your skin. Hesperidin methyl chalcone is also listed as an ingredient in a number of facial creams and lotions that treat skin redness.
Glucosyl hesperidin is a A water-soluble form of hesperidin. Hesperidin is a flavonoid found in various plants such as citrus and evening primrose oil. It has potential as a potent antioxidant. Unfortunately, it has not been proven to have an effect on cellulite.
Photochemistry and Photobiology, September 2003, pages 256–261
Phytotherapy Research, December 2001, pages 655–669
Anticancer Research, July-August 1999, pages 3237–3241
International Angiology, September 2003, pages 250–262