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Acetyl hexapeptide-3 is a peptide claimed to intercept and stop the transmission of the chemical signal responsible for the muscle contractions that can lead to fine line and wrinkle formation, while also helping reduce the depth of existing wrinkles. Acetyl hexapeptide-3 is used primarily in anti-aging and anti-wrinkle creams, as well as in eye creams.
Also known as Argireline, this ingredient temporarily inhibits the neurotransmitter neuroepinephrine (like Botox does), and effects of topically-applied argireline are temporary. Even the most concentrated dose of topical argireline on the market today is not likely to last for more than 8 hours at a time. This ingredient is used in skin care products by companies claiming that it has a muscle-relaxing effect similar to Botox injections.

It is an artificially created peptide (a chain of six amino acids) developed by a Spanish company. It is claimed to relax muscle contractions within minutes of application. It does not paralyze muscles like Botox but reduces muscle contractions. In testing, acetyl hexapeptide-3 reduced wrinkle depth by reportedly 27 percent after thirty days of daily use, the company says. Long-term use of this active ingredient is supposed to produce a benefit similar to Botox and lines can become more shallow and less pronounced in time. Little scientific research has been done to prove this works, which doesn’t mean that it may be without value.


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