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What is Acetyl Hexapeptide-38?

Acetyl Hexapeptide-38 functions in skincare and cosmetics as a peptide that the (obviously biased) manufacturer claims can restore youthful curves by redistributing volume; plump up fine lines and wrinkles from within; and redefine facial contours.

More information on Acetyl Hexapeptide-38

Acetyl Hexapeptide-38 is the product obtained by the acetylation of Hexapeptide-38.

According to the manufacturer, Acetyl Hexapeptide-38 peptide is the perfect ingredient to diminish the effects that the aging process causes in the skin. In facial formulations, it can increase the supporting tissue beneath the skin, improving facial appearance. In body products, it can be used to enhance the volume of certain areas like breast or buttocks.

In the face, adipose tissue is mostly found beneath the skin and acts as supporting tissue. In the breast, adipose tissue is a high percentage of the total gland composition. It has an essential role in defining breast shape and size.

Acetyl Hexapeptide-38 peptide stimulates PGC-1± expression, enhancing adipogenesis rate. This leads to a higher lipid accumulation and volume growth in the desired areas like breast and cheeks.

In Vitro Test

Promoted PCG-1a expression by more than 61%.
Lipid accumulation is higher by 32.4% in treated cells.
In Vivo Test on Volunteers

Cheek volume increased 12% after 14 days with the Adifyline® peptide 2% solution in 22 female volunteers aged 50 to 60.
Breast volume increased after 56 days by 30x compared to placebo treatment in 22 females between 25 and 40 years old.

Cosmetic Benefits Claims
  • Restores youthful curves by redistributing volume
    Plumps up fine lines and wrinkles from within
    Redefines facial contours

Acetyl Hexapeptide-38 peptide can be incorporated in many formulations and products to increase local volume. This includes facial redefining products, breast firming formulations, facial anti-aging products, make up for mature women, lip care products and make up, specific formulations for the cleavage area (mature women), and anti-aging products for hands, which lose adipose tissue with age. Moreover, it can also be incorporated as a complementary ingredient in hydrating, firming and sun care products for specific body care areas (buttocks and breast) with a replenishing effect.

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