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The fresh garlic bulb contains alliin, alicin and volatile oils and when garlic clove is crushed, the odorless compound alliin is converted to allicin via the enzyme allinase. This compound has been used in the past to treat skin infections such as athlete’s foot; however, too much exposure to garlic can result in blistered skin.

Adverse reactions, related to garlic are potentially consist of irritant contact dermatitis, allergic contact dermatitis, protein contact dermatitis, zosteriform dermatitis, contact urticaria and induction of pemphigus.

Garlic has a high sulfur content, arginine, oligosaccharides, flavonoids, as well as selenium and vitamin E. Most of the studies done on garlic and how great it is, have to do with eating it, not using an extract of garlic applied to skin. However, that hasn’t stopped companies (like Pierre Fabre) from registering patents on garlic, some for treating cellulite.

Of the dermatological studies on garlic extract, one review has summarized all dermatologic-oriented in vitro and in vivo experiments and clinical trials on garlic preparations. Extensive literatures search was carried out and twenty three studies were included.

The results suggest that oral administration of garlic is effective on immunologic properties, cutaneous microcirculation, protection against UVB and cancer treatment. Additionally, topical application of garlic extract can potentially be effective on psoriasis, alopecia areata, keloid scar, wound healing, cutaneous corn, viral and fungal infection, leishmaniasis, skin aging and rejuvenation. Clinical effectiveness of oral and topical garlic extract is not sufficiently and meticulously explored as so far.

Report Praises the Skin and Health Benefits of Garlic
Recent US Patents (P) and Patent applications (PA) for anticellulite ingredients
Garlic in dermatology

1. Yilmaz HH, Gormez O, Hastar E, et al. Garlic burn in a patient with trigeminal neuralgia: a case report.Eur J Dent. 2010;4:88–90. [PMC free article] [PubMed]
2. Cultivation Garlic. [Accessed march/23/2011]; Available at: https:// h%20ig.htm.
3. Aviello G, Abenavoli L, Borrelli F, et al. Garlic: empiricism or science? Nat Prod Commun.2009;4:178517–96. [PubMed]
4. Kasuga S, Uda N, Kyo E, et al. Pharmacologic activities of aged garlic extract in comparison with other garlic preparations. J Nutr. 2001;131:1080S–4S. [PubMed]
5. Amagase H. Clarifying the real bioactive constituents of garlic. J Nutr. 2006;136:716S–725S. [PubMed]
6. Allison GL, Lowe GM, Rahman K. Aged garlic extract and its constituents inhibit platelet aggregation through multiple mechanisms. J Nutr. 2006;136:782S–788S. [PubMed]
7. Arnault I, Auger J. Seleno-compounds in garlic and onion. J Chromatogr A. 2006;1112:23–30. [PubMed]
8. Lanzotti V. The analysis of onion and garlic. J Chromatogr A. 2006;1112:3–22. [PubMed]
9. Sumiyoshi H. New pharmacological activities of garlic and its constituents. Nippon Yakurigaku Zasshi.1997;1101:93P–7P. [PubMed]
10. Jappe U, Bonnekoh B, Hausen BM, Gollnick H. Garlic-related dermatoses: case report and review of the literature. Am J Contact Dermat. 1999;10:37–9. [PubMed]
11. Borek C. Antioxidant health effects of aged garlic extract. J Nutr. 2001;131:1010S–5S. [PubMed]
12. Imai J, Ide N, Nagae S, et al. Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Planta Med. 1994;60:417–20. [PubMed]
13. Jung EM, Jung F, Mrowietz C, et al. Influence of garlic powder on cutaneous microcirculation. A randomized placebo-controlled double-blind cross-over study in apparently healthy subjects.Arzneimittelforschung. 1991;41:626–30. [PubMed]
14. Chandrashekar PM, Venkatesh YP. Identification of the protein components displaying immunomodulatory activity in aged garlic extract. J Ethnopharmacol. 2009;124:384–90. [PubMed]
15. Lamm DL, Riggs DR. Enhanced immunocompetence by garlic: role in bladder cancer and other malignancies. J Nutr. 2001;131:1067S–70S. [PubMed]
16. Arnault I, Auger J. Seleno-compounds in garlic and onion. J Chromatogr A. 2006;1112:23–30. [PubMed]
17. Milner JA. Preclinical perspectives on garlic and cancer. J Nutr. 2006;136:827S–31S. [PubMed]
18. Wang HC, Yang JH, Hsieh SC, Sheen LY. Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis. J Agric Food Chem. 2010;58:7096–103.[PubMed]
19. Pratheeshkumar P, Thejass P, Kutan G. Diallyl disulfide induces caspase-dependent apoptosis via mitochondria-mediated intrinsic pathway in B16F-10 melanoma cells by up-regulating p53, caspase-3 and down-regulating pro-inflammatory cytokines and nuclear factor-κβ-mediated Bcl-2 activation. J Environ Pathol Toxicol Oncol. 2010;29:113–25. [PubMed]
20. Hakimzadeh H, Ghazanfari T, Rahmati B, Naderimanesh H. Cytotoxic effect of garlic extract and its fractions on Sk-mel3 melanoma cell line. Immunopharmacol Immunotoxicol. 2010;32:371–5. [PubMed]
21. Lamm DL, Riggs DR. The potential application of Allium sativum (garlic) for the treatment of bladder cancer. Urol Clin North Am. 2000;27:157–62. [PubMed]
22. Reeve VE, Bosnic M, Rozinova E, Boehm-Wilcox C. A garlic extract protects from ultraviolet B (280–320 nm) radiation-induced suppression of contact hypersensitivity. Photochem Photobiol. 1993;58:813–7.[PubMed]
23. Aggarwal BB, Shishodia S. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann N Y Acad Sci. 2004;1030:434–41. [PubMed]
24. Hajheydari Z, Jamshidi M, Akbari J, Mohammadpour R. Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: a double-blind randomized controlled study. Indian J Dermatol Venereol Leprol. 2007;73:29–32. [PubMed]
25. Feily A, Namazi MR, Pazyar N, et al. Garlic extract as a novel addition to antikeloid armamentarium: an untested hypothesis. J Altern Complement Med. 2009;15:1153–4. [PubMed]
26. Bojs G, Svensson A. Contact allergy to garlic used for wound healing. Contact Dermatitis. 1988;18:179–81. [PubMed]
27. Ejaz S, Chekarova I, Cho JW, et al. Effect of aged garlic extract on wound healing: a new frontier in wound management. Drug Chem Toxicol. 2009;32:191–203. [PubMed]
28. Lipke MM. An armamentarium of wart treatments. Clin Med Res. 2006;4:273–93. [PMC free article][PubMed]
29. Dehghani F, Merat A, Panjehshahin, Handjani F. Healing effect of garlic extract on warts and corns. Int J Dermatol. 2005;44:612–5. [PubMed]
30. Yousuf S, Ahmad A, Khan A, et al. Effect of garlic-derived allyl sulphides on morphogenesis and hydrolytic enzyme secretion in Candida albicans. Med Mycol. 2010 Dec 3; [Epub ahead of print] [PubMed]
31. Ledezma E, López JC, Marin P, Romero H, et al. Ajoene in the topical short-term treatment of tinea cruris and tinea corporis in humans. Randomized comparative study with terbinafine. Arzneimittel-forschung.1999;49:544–7. [PubMed]
32. Ledezma E, Marcano K, Jorquera A, et al. Efficacy of ajoene in the treatment of tinea pedis: a double-blind and comparative study with terbinafine. J Am Acad Dermatol. 2000;43:829–32. [PubMed]
33. Ledezma E, DeSousa L, Jorquera A, et al. Efficacy of ajoene, an organosulphur derived from garlic, in the short-term therapy of tinea pedis. Mycoses. 1996;39:393–5. [PubMed]
34. Gamboa-León MR, Aranda-González I, Mut-Martí­n M, et al. In vivo and in vitro control of Leishmania mexicana due to garlic-induced NO production. Scand J Immunol. 2007;66:508–14. [PubMed]
35. Gholami AR, Khamesipour A, Momeni A, et al. Treatment of cutaneous leishmaniasis with 5% garlic cream: A randomized, double-blind study. Iran J Derm. 2000;3:2–6.
36. Svendsen L, Rattan SI, Clark BF. Testing garlic for possible anti-ageing effects on long-term growth characteristics, morphology and macromolecular synthesis of human fibroblasts in culture. J Ethnopharmacol.1994;43:125–33. [PubMed]

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