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What is N-Hydroxysuccinimide?

You’ll often see chrysin and N-hydroxysuccinimide listed one after the other on ingredient lists for eye products (usually targeting dark circles). Chrysin and N-hydroxysuccinimide activate the elimination of blood originated pigments responsible for the color of dark circles and local inflammation. Infra-orbital shadows are due to the accumulation of haemoglobin and its coloured degradation products – biliverdin, bilirubin and iron – in the dermis and epidermis. Chrysin stimulates the enzyme (UGT1A1) leading to the clearance of bilirubin. N-hydroxysuccinimide renders the iron soluble for natural elimination.

More information on N-Hydroxysuccinimide

This ingredient is slightly acidic, and is an known irritant to skin, eyes and mucous membranes. I was unable to find much research on it.

Haloxyl is a trademarked blend of water, glycerin, steareth-20, N-hydroxysuccinimide, chrysin, palmitoyl oligopeptide, and palmitoyl tetrapeptide-7. It’s one of the blends the cosmetic raw material supplier Croda sells that claim to help dark circles and eye puffiness.

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