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“Research has shown that resveratrol applied to skin seems to have a stimulating and protective effect on glutathione, the body’s master antioxidant.”

Polygonum cuspidatum or Giant Knotweed or Japanese Knotweed owes its antioxidant benefits to its resveratrol content. It is a traditional Chinese Medicine used for circulation and heart health. Resveratrol has been shown to exert an antiinflammatory and antiaging effects in vitro and in animal models. However, these studies had subjects take resveratrol supplements, not use a skin cream containing resveratrol.

Resveratrol is a member of a group of plant compounds called polyphenols. Resveratrol is found in the skin of red grapes, but other sources include peanuts and berries. Most resveratrol capsules sold in the U.S. contain extracts from the Japanese and Chinese knotweed plant Polygonum cuspidatum. Other resveratrol supplements are made from red wine or red grape extracts.

Sources
Free Radical Biology and Medicine, October 2014, pages 213-223
Anticancer Research, September–October 2004, pages 2783–2840
Medicinal Chemistry, November 2005, pages 629–633
Molecular Nutrition and Food Research, May 2005, pages 405–430
Antioxidant Redox Signal, December 2001, pages 1041–1064
Mutation Research, Genetic Toxicology and Environmental Mutagenesis, September 2001, pages 171–180
An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol
https://examine.com/supplements/japanese-knotweed/
Biological & Pharmaceutical Bulletin, January 1995, pages 162–166

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