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iS Clinical Pro-Heal Serum Advance Plus

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Water, 15% L-Ascorbic Acid¹, Laureth-4, Alcohol Denat.¹⁰, Pentylene Glycol⁵, Propylene Glycol⁴, Olea Europaea (Olive) Leaf Extract⁶, Zinc Sulfate², 1% Tocopherol, Polyporus Umbellatus (Mushroom) Extract, Arbutin⁹, Glycerin⁷, Bioflavonoids⁸, 1% Retinol³, Polysorbate 20, Phenoxyethanol

Ingredient	What it does
¹ascorbic acid	an antioxidant proven to give you photoprotection by preventing oxidation & inflammation; boosts collagen production; can lighten hyperpigmentation if the concentration is high enough; also used as pH adjuster/buffering agent; fragrance ingredient
²zinc sulfate	astringent; irritant
³retinol	Proven antioxidant anti-wrinkle treatment; induces collagen synthesis, increases skin elasticity, smoother skin & skin lightening effects; treats hyperpigmentation
⁴propylene glycol	solvent; humectant; gives a product "slip"; helps "carry" other ingredients into the skin; also enhances the efficacy of preservatives
⁵pentylene glycol	synthetic humectant moisturizer; also a solvent & anti-microbial preservative
⁶olea europaea (olive) leaf extract	anitimicrobial actions of oleuropein has been proven in vivo; proven to reduce skin damage & carcinogenesis
⁷Glycerin	A humectant moisturizer; usually used as a base in (light) moisturizers
⁸Bioflavonoids	soothing moisturizer
⁹arbutin	lightened skin in in vitro studies, from hydroquinone; it's unclear how much is needed to show whitening effects. Low concentrations have no effect, while high concentrations of about 5% or more can be as irritating as hydroquinone & may potentially result in unexpected hyperpigmentation
¹⁰Alcohol Denat.	masking, solvent to dissolve things in a formula, viscosity controlling

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Ingredient List iS Clinical Treatments